Avi Ma’ayan, Ph.D., is an Assistant Professor in the Department of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine, New York, NY, USA. His interests are in applying graph theory, machine learning, dimensionality reduction, dynamical modeling, and visualization methods for integrating “omics” datasets collected from mammalian sources to better understand biological regulation on a global scale. Ben D. MacArthur, Ph.D., is a Lecturer in Mathematics at the Life Science Interface in the Schools of Mathematics and Medicine at the University of Southampton, UK. His interests are in applying mathematical methods to problems in cell and molecular biology including modeling of cell fate, analysis of the structure and function of biological regulatory networks, and high throughput data analysis and bioinformatics.