C. Ronald MacKenzie, MD, Professor of Clinical Medicine and Medical Ethics, Attending Physician, Departments of Rheumatology and Medicine, Weill Cornell Medical College, Hospital for Special Surgery, New York, NY, USACharles N. Cornell, MD, Professor of Clinical Orthopedic Surgery, Attending Orthopedic Surgeon, Department of Orthopedics, Weill Cornell Medical College, Hospital for Special Surgery, New York, NY, USAStavros G. Memtsoudis, MD, PhD, MBA, Clinical Professor of Anesthesiology and Health Policy and Research, Attending Anesthesiologist and Senior Scientist Director of Critical Care Services Department of Anesthesiology Critical Care, and Pain Management, Weill Cornell Medical College, Hospital for Special Surgery, New York, NY, USA