Professor Cacuci’s career spans over 40 years in the field of nuclear science and energy, encompassing both academia and large-scale multidisciplinary research centers. His scientific expertise includes predictive best-estimate analysis of large-scale physical and engineering systems, large scale scientific computations and, within nuclear science and engineering, reactor multi-physics, dynamics, and safety. During the period 1990-2012, Prof. Cacuci served as Director of the Institute of Reactor Safet at the Research Center Karlsruhe and Chaired Professor at the University of Karlsruhe in Germany, and also served as the Scientific Director of The French Alternative Energies and Atomic Energy Commission’s Nuclear Energy Pole. During the period 1984-2019, Prof. Cacuci served as the Editor of “Nuclear Science and Engineering,” a research journal of the American Nuclear Society, and is serving since 2019 as the Founding Editor-in-Chief of the open access MDPI Journal of Nuclear Engineering. He has received many prestigious awards, including four titles of Doctor Honoris Causa, the E. O. Lawrence Award and Gold Medal from the US DOE, the Alexander von Humboldt Prize for Senior Scholars and from the American Nuclear Society, the Arthur Holly Compton Award, the Eugene P. Wigner Award, the Glenn Seaborg Medal, Young Members Engineering Achievement Award, and ANS Fellow. He is a member of several international and national academies of arts and sciences, has made over 600 presentations worldwide, has authored 46 books, 7 book chapters, over 200 peer-reviewed articles, and has edited the comprehensive Handbook of Nuclear Engineering. Currently, Prof Cacuci serves as the Director of the Center of Economic Excellence in Nuclear Science and Energy and SmartState Endowed Chair Professor of Mechanical Engineering at University of South Carolina.