Professor Cacuci’s career spans over 40 years in the field of nuclear science and energy, encompassing both academia and national multidisciplinary research centers. His scientific expertise includes predictive best-estimate analysis of large-scale physical and engineering systems, large scale scientific computations and, within nuclear science and engineering, reactor multi-physics,dynamics, and safety. Prof. Cacuci served as the Chaired Professor and Director of the Institutes for Reactor Technology (Uni Karlsruhe/KIT) and Reactor Safety (KfK/FZK/KIT) and has also served as the Scientific Director of the Nuclear Energy Directorate of France’s Atomic Energy Commission. During 1984-2019, Prof. Cacuci was the Editor of Nuclear Science and Engineering; since 2019, he has been serving as the Founding Editor of the open-access Journal of Nuclear Engineering (MDPI). Prof. Cacuci has received many prestigious awards, including four titles of Doctor Honoris Causa, the E. O. Lawrence Award and Gold Medal from the US DOE, the Alexander von Humboldt Prize for Senior Scholars; from the American Nuclear Society (ANS), he has received the Arthur Holly Compton Award, the Eugene P. Wigner Award, the Glenn Seaborg Medal, Young Members Engineering Achievement Award, and was elected an ANS Fellow. He is a member of several international and national academies of arts and sciences, has made over 600 presentations worldwide, has authored 6 books, 6 book chapters, over 300 peer-reviewed articles, and has edited the comprehensive Handbook of Nuclear Engineering (Springer, 2010). He is currently the Director of the Center of Economic Excellence in Nuclear Science and Energy and SmartState Endowed Chair Professor of Nuclear Engineering at University of South Carolina.Dr. Fang is a Research Associate Professor in the Department of Mechanical Engineering at the University of South Carolina, performing research on predictive modeling of large-scale physical and engineering systems with applications in the broad areas of thermal science, nuclear science and energy. He received his B.S. from the Thermal Power Engineering at Xi’an Jiaotong University, China; and M.E. and Ph.D. degrees from the Department of Mechanical Engineering at the University of South Carolina in 2011. Dr. Fang has authored over 50 peer-reviewed articles in thermal-hydraulic safety analysis for liquid-metal cooled advanced Small Modular Reactors, facility modeling for separation and safeguards, and thermal management of all-electric ship’s power electronic systems.