Nabil Semmar has Ph.D. in phytochemistry with a multidisciplinary training pattern combining applied statistical analyses to different biological fields including environmental sciences (marine, terrestrial: bachelor degree), biotechnologies (master) and pharmacology (postdoctoral researches). In his Ph.D. (Lyon, 2000), he studied the flavonoids and saponins in the leaves and roots of Astragalus caprinus (Fabaceae). During his Ph.D., he developed a new simulation approach based on simplex rule (mass conservation law) helping for computational analysis of metabolic pathways and chemical polymorphism at population scale from HPLC data. Publication of this approach was followed by the invitation of N. Semmar by IAEA (Vienna, 2008) for conference and project discussion. Nabil Semmar carried out several correlation analyses between quantitative and qualitative aspects of secondary metabolites (as well as primary metabolites and drugs) leading to highlight mass distributionand metabolic regulation processes governing structural variability and sequential biosynthesis ways in plant matrices, pharmacological systems and environment.