Télécharger le livre :  Hepatitis C Virus: From Molecular Virology to Antiviral Therapy
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Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific...

Editeur : Springer
Parution : 2013-03-12
Collection : Current Topics in Microbiology and Immunology
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147,69
Télécharger le livre :  Systems Biology
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First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological...

Editeur : Springer
Parution : 2013-01-04
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  Botulinum Neurotoxins
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The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon....

Editeur : Springer
Parution : 2012-12-14
Collection : Current Topics in Microbiology and Immunology
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158,24
Télécharger le livre :  Therapeutic Kinase Inhibitors
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Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as “chemotherapy” and still the backbone of most cancer treatment regimens, are increasingly...

Editeur : Springer
Parution : 2012-11-27
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  Phosphoinositides and Disease
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Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their...

Editeur : Springer
Parution : 2012-10-20
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  Notch Regulation of the Immune System
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Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident thatNotch...

Editeur : Springer
Parution : 2012-09-13
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  Henipavirus
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Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular...

Editeur : Springer
Parution : 2012-09-05
Collection : Current Topics in Microbiology and Immunology
ePub

179,34
Télécharger le livre :  Pasteurella multocida
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This volume brings together contributions from experts in the field of Pasteurella research. Its covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of PMT and its interaction with host...

Editeur : Springer
Parution : 2012-09-03
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  Ricin and Shiga Toxins
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 In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths.  While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant...

Editeur : Springer
Parution : 2012-02-10
Collection : Current Topics in Microbiology and Immunology
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147,69
Télécharger le livre :  Epigenetic Regulation of Lymphocyte Development
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The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that...

Editeur : Springer
Parution : 2012-02-07
Collection : Current Topics in Microbiology and Immunology
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147,69
Télécharger le livre :  Mucosal Vaccines
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This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal...

Editeur : Springer
Parution : 2012-01-10
Collection : Current Topics in Microbiology and Immunology
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147,69
Télécharger le livre :  Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
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“The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they  act to affect gene expression and  function.  It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate...

Editeur : Springer
Parution : 2011-11-06
Collection : Current Topics in Microbiology and Immunology
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147,69
Télécharger le livre :  Intradermal Immunization
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This volume of Current Topics in Microbiology and Immunology covers diverse topics related to intradermal immunization. The  chapters highlight the effectiveness of intradermal immunization in experimental animal models or in clinical practice, all supporting the view...

Editeur : Springer
Parution : 2011-09-15
Collection : Current Topics in Microbiology and Immunology
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147,69
Télécharger le livre :  Vaccines against Allergies
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We are celebrating this year the hundred years´ anniversary of allergen-specific immunotherapy. In 1911 Leonard Noon published his seminal work “Prophylactic inoculation against hay fever” describing his attempts to achieve active immunity against “grass pollen toxin”...

Editeur : Springer
Parution : 2011-08-26
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  NF-kB in Health and Disease
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Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival,...

Editeur : Springer
Parution : 2011-04-26
Collection : Current Topics in Microbiology and Immunology
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147,69
Télécharger le livre :  Cancer Immunology and Immunotherapy
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The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies.The present review discusses tumor-immune...

Editeur : Springer
Parution : 2011-04-11
Collection : Current Topics in Microbiology and Immunology
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210,99
Télécharger le livre :  Negative Co-Receptors and Ligands
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Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or...

Editeur : Springer
Parution : 2011-04-11
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  Small-Molecule Inhibitors of Protein-Protein Interactions
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In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique...

Editeur : Springer
Parution : 2011-01-18
Collection : Current Topics in Microbiology and Immunology
ePub

147,69
Télécharger le livre :  Phosphoinositide 3-kinase in Health and Disease
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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K...

Editeur : Springer
Parution : 2010-10-17
Collection : Current Topics in Microbiology and Immunology
ePub

210,99
Télécharger le livre :  Phosphoinositide 3-kinase in Health and Disease
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PI3K has become a very intense area of research, with over 2000 publications onPI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention withPI3K activity are high, and progress in the clinical arena is being monitored by many. However,...

Editeur : Springer
Parution : 2010-10-17
Collection : Current Topics in Microbiology and Immunology
ePub

210,99
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