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Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that...
Editeur :
Springer
Parution :
2011-06-21
Collection :
Handbook of Experimental Pharmacology
ePub
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Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry.The book starts with an introduction treating...
Editeur :
Springer
Parution :
2011-05-10
ePub
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"Aromatic Hyroxyketones: Preparation and Physical Properties" is a revised, new edition 4-volume handbook set which provides detailed information on physical properties and syntheses on a wide range of hydroxyketones. Each entry includes characterization data such as...
Editeur :
Springer
Parution :
2011-01-30
ePub
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A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a...
Editeur :
Springer
Parution :
2011-01-20
ePub
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A concise overview of tissue engineering technologies and materials towards specific applications, both past and potential growth areas in this unique discipline is provided to the reader. The specific area of the biomaterial component used within the paradigm of tissue...
Editeur :
Springer
Parution :
2010-12-07
ePub
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Editeur :
Springer
Parution :
2010-09-09
ePub
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The aim of this book is to return to the biomimicry and medicinal potential that inspired many of the early supramolecular chemists and to set it in the context of current advances in the field.
Following an overview of supramolecular chemistry, the first section...
Editeur :
Springer
Parution :
2010-08-26
ePub
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The second edition of this book has drawn heavily on the first edition but a huge amount of research on steroid analysis has been published over the last 15 years. As a result, the Editors decided to let the first edition of this book stand on its own and direct readers...
Editeur :
Springer
Parution :
2010-06-04
ePub
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High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of...
Editeur :
Springer
Parution :
2010-03-12
Collection :
Topics in Medicinal Chemistry
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Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of...
Editeur :
Humana
Parution :
2010-02-06
ePub
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Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in...
Editeur :
Springer
Parution :
2009-12-17
ePub
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Molecular and Cellular Enzymology addresses not only experienced enzymologists but also students, teachers and academic and industrial researchers who are confronted with enzymological problems during their fundamental or applied research. In this field there is an...
Editeur :
Springer
Parution :
2009-12-05
ePub
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The important role of ?nely dispersed matter and surfaces in medicine is not always fully understood and appreciated. Speci?cally, ?ne particles (solid or liquid) in the size range of several nanometers to several micrometers have a tremendous effect on our lives,...
Editeur :
Springer
Parution :
2008-12-05
PDF, ePub
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This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of...
Editeur :
Springer
Parution :
2008-05-27
ePub
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In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged: Microreactor chemistry;...
Editeur :
Springer
Parution :
2007-06-02
PDF, ePub
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Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the...
Editeur :
Springer
Parution :
2007-05-26
PDF
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9-Borabicyclo [3.3.1]nonane, a commercially available reagent, is the most versatile hydroborating reagent to synthesize organoboranes (B-R-9-BBN). The reagent exhibits remarkable regio-, chemo-, and stereoselectivity during hydroboration reactions. The organoboranes...
Editeur :
Springer
Parution :
2007-05-01
PDF
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Clinical Trial Registries: A Practical Guide for Sponsors and Researchers of Medicinal Products is a necessary addition to the library of all researchers who plan to publish their results in top-tier, peer-reviewed journals. ICMJE editors and other journal editors...
Editeur :
Birkhäuser
Parution :
2006-11-09
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