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Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and...
Editeur :
Springer
Parution :
2022-09-28
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The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology.The authors review...
Editeur :
Springer
Parution :
2022-09-10
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The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based...
Editeur :
Springer
Parution :
2022-05-17
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This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as...
Editeur :
Springer
Parution :
2022-04-22
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This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds. Chapter 1 delves into the chemistry of pyrogallols and their oxidized products, the hydroxy-o-quinones, including their role in cycloaddition reactions in the...
Editeur :
Springer
Parution :
2022-04-13
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This book introduces the recent development in Japan of diamond electrodes, which has attracted much attention in the world. For example, electrochemical sensors using diamond electrodes are now being utilized commercially. Newly developing applications such as...
Editeur :
Springer
Parution :
2022-03-15
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A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book...
Editeur :
Springer
Parution :
2022-03-07
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Given novel infectious diseases such as COVID-19 and antibiotic resistance new antimicrobial discovery is an important research area. Considering that nature is a vast source of bioactive molecules with antimicrobial activity, the main aim of this book is to present a...
Editeur :
Springer
Parution :
2022-02-03
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This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical...
Editeur :
Springer
Parution :
2022-01-02
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This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds.
Prepared by expert contributors, the respective chapters...
Editeur :
Springer
Parution :
2021-12-08
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This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery,...
Editeur :
Springer
Parution :
2021-10-18
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This book focuses on the new and old methods for the synthesis of various heterocycles using Lawesson’s reagent. The book covers an important and rapidly growing branch of heterocyclic chemistry and can serve as a guide to those who are completing their education and...
Editeur :
Springer
Parution :
2021-09-10
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This book presents recent advances in the use of ionic liquids in medicine and pharmaceutics with particular emphasis on addressing critical pharmaceutical challenges, including the low solubility, polymorphism, and bioavailability of drugs. It also provides insights...
Editeur :
Springer
Parution :
2021-08-27
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This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex...
Editeur :
Springer
Parution :
2021-07-13
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This book presents the synthetic methodologies as well as the properties and potential usage of various ruthenium-containing materials. Starting from the first examples of 'ruthenopolymers' reported in the 1970s to the 3D architectures now synthesized, these materials...
Editeur :
Springer
Parution :
2021-06-17
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This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is...
Editeur :
Springer
Parution :
2021-04-05
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This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in...
Editeur :
Springer
Parution :
2021-04-02
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This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high...
Editeur :
Springer
Parution :
2021-04-01
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This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized...
Editeur :
Springer
Parution :
2021-03-25
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This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry...
Editeur :
Springer
Parution :
2021-03-23
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